World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

GC-MS ANALYSIS AND BIOLOGICAL ACTIVITY OF SUDANESE CITRULLUS LANATUS L.(CUCURBITACEAE) FIXED OIL

Abdel Karim. M.,1* Balsam,O.2 and Inas,O.3

ABSTRACT

The present study was designed to investigate the chemical constituents of Citrullus lanatus seed oil and to evaluate its potential antimicrobial activity. 25 components were detected by GC-MS analysis. Major constituents are: 9,12-octadecadienoic acid(48.47%), hexadecanoic acid(17.51%),), 9-octadecenoic acid (15.10%), and methyl stearate(12.96%). The antimicrobial activity of the oil was evaluated via cup plate agar diffusion assay against six standard human pathogens(Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the fungi Candida albicans and Aspergillus niger). The oil showed different antimicrobial responses against test organisms. It was partially active against Eschericha coli, Pseudomonas aeruginosa and the fungus Candida albicans, but it exhibited significant activity against Staphylococcus aureus.

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