World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

EVALUATION OF EFFICACY OF TACROLIMUS AND TRIAMCINOLONE ACETONIDE OINTMENT IN THE MANAGEMENT OF SYMPTOMATIC ORAL LICHEN PLANUS: A COMPARATIVE STUDY

Tapaswini Bag*, Laxmikanth Chatra, Prashanth Shenai, Veena K M, Prasanna Kumar Rao, Rachana V Prabhu, Tashika Kushraj and Shahul Hameed

ABSTRACT

Introduction: Oral lichen planus (OLP) is a relatively common, chronic inflammatory condition and presumably autoimmune disease, which frequently present with burning sensation. Only symptomatic OLP requires treatment and efforts were made in a continued searching for novel therapies for symptomatic OLP. Aim: The study was aimed to compare the efficacy of treatment with topical tacrolimus with that of triamcinolone acetonide in orabase in subjects with symptomatic OLP. Materials and Methods: This prospective randomized comparative study, included 30 symptomatic OLP subjects, divided into two groups as group A and group B to recieve topical tacrolimus 0.03% ointment and triamcinolone acetonide 0.1% in orabase application respectively, twice daily for four consecutive weeks. Burning sensation using visual analogue scale (VAS) scale was recorded at every visit. The data obtained was analyzed statistically by using Friedman & Man-Whitney test. Results: Subjects showed a higher (97%) reduction of burning sensation, erythematous area and size of the lesion in group A than in group B (77%). Interpretation and conclusion: Group A induced better therapeutic response than group B. No significant adverse effects were observed and no recurrence was noted during the treatment. Topical tacrolimus has been reported to be effective treatment for OLP, including those forms that had been recalcitrant to treatment. However, studies involving larger samples & longer period of treatment, follow-up are suggested in the future.

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