World Journal of
Pharmaceutical and Life Sciences

SYNTHESIS & SPECTROSCOPIC INVESTIGATION OF CU(II), CO(II) AND ZN(II) COMPLEXES OF AZO DYE DERIVED FROM CALIX[4]RESORCINARENE AND THEIR BIOLOGICAL SCREENING

Hrishikesh S. Gupte, Keyur Bhatt, Vinod K. Jain and Bharat A. Makwana*

ABSTRACT

The chemistry of metal complexation containing azo group has been a subject of greater interest in the 21st century. Novel azo dye derived from o-amino phenol and calix[4] resorcinarene having a conjugated chromophoric azo (-N=N-) group in upper-rim was synthesized by microwave irradiation technique. This compound in the solid and solution form is elucidated by FT-IR, 1H-NMR, 13C-N MR, as well as elemental analysis technique. Bivalent metal [Copper, Cobalt, and Zinc] complexes of azo-calix[4] resorcinarene were synthesized in different molar ratio of metal and ligand in alcoholic medium under different pH condition if required. The chemistry of all these complexes is presented here with special attention given to their synthesis, structure, spectral and various other properties. These complexes were studied by UV, IR, TGA, DTA, and ESR techniques. AAS of metal ions reviewed that 4:1 (M:L) complex is established. The stoichiometry of the azo-metal chelates was also determined by the spectroscopic titration method. These complexes have shown slightly increased biological activity on S.aureus and E.coli respectively compared to ligand.

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