World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

EVALUATION OF SAFETY AND IMPROVEMENT OF GLOBAL LEFT VENTRICULAR FUNCTION AFTER REPERFUSION THERAPY IN ACUTE MYOCARDIAL INFARCTION PATIENTS

Ranakishore Pelluri* M. Ramesh, Yedluri Divya, Psupuleti Keerthi, Nakka Varshitha, Jampani Poorna Sindhu, P. Srinivasababu

ABSTRACT

Early reperfusion has been shown to improve left ventricular function and survival after acute myocardial infarction. Anterior wall infarction carries a worse prognosis than inferior or lateral wall infractions because it is more commonly associated with development of left ventricular failure and cardiogenic shock. In our study there are AMI patients with low LVEF, ejection fraction can be improved by administration of thrombolytis. The purpose of this study is to compare the efficacy of improvement of LVEF more than 55%. In our observation we conclude that Retiplase has more effectively improves the ejection fraction than streptokinase. Objective: To evaluate the relation between improvements in global left ventricular ejection fraction during throbolysis in acute myocardial infarction patients and their mortality and safety. Methods: This is an observational study involves a total number of 120 patients. Patients were diagnosed with Acute ST-segment elevation myocardial infarction (STEMI). Patients are allocated into two groups. Streptokinase and another retiplase received group. Based on ECG characteristics, AMIs are further categorized based on locations of infractions as anterior, inferior, posterior, antero posterior, infero posterior wall myocardial infarctions. Thrombolytics was administered after receiving patient consent. The global LVEF was measured before and after throbolysis by the expertise using echocardiography. A left ventricular ejection fraction of ? 55% was considered a normal systolic function. The safety parameters such as anaphylaxis, cerebro vascular accident (CVA), hypotension, bleeding and mortality were observed among those patients after thrombolysis. Results: A baseline 26 patients of < 55% of LVEF was noticed in SK group & 35 patients in RTP group. After throbolysis improvement of global LVEF > 55% was observed only in 6 patients, out of 26 patients in SK group after thrombolysis. In RTP group baseline 35 patients are observed with <55% of LVEF, after thrombolysis with RTP > 55% of LVEF observed in 15 patients out of 35 patients those who have less than 55 % . That indicates there was significant improvement of LVEF > 55% observed in RTP received group and it was considered to be effective as compare with SK. Side effects and mortality is also less with RTP received group. Conclusion: Thrombolytics were administered within 6 hours of symptoms onset. Thrombolysis with RTP was significantly more likely to improve their global LVF in patients with STEMI as compared with SK. By observing this findings we conclude that RPT was considered to be safe and effective.

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