World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

BIOLOGICAL EVALUATION OF ETHYL-2-METHYLQUINOLINE-3-CARBOXYLATE IN MYOCARDIAL ISCHAEMIA REPERFUSION INJURY

Sharma Poonam*, Kaur Kamaldeep, Chawla Amit, Dhawan R.K.

ABSTRACT

Isolated perfused heart preparation has been employed in the present study because it permits the use of pharmacological interventions without any interference due to changes in systemic circulation. Electrical pacing has not been used in this study because it is reported to release norepinephrine. Oxidative stress parameters in the present study have been assessed spectrophotometrically. PGC-1? interacts with GCN-5, an acetyl-transferase that has been shown to acetylate and inhibit PGC-1? activity in vitro and in vivo. PGC-1? levels are reduced in heart following MI by coronary artery ligation in rats while treatment with angiotensin II receptor blockers. Moreover, impairment of the PGC-1?-mediated mitochondrial biogenesis increased heart vulnerability to IRI and up-regulation of PGC-1? pathway confers protection against simulated I/R in cardio-myoblast cells.

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