World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

FORMULATION AND DEVELOPMENT OF ENALAPRIL MALEATE FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD AND ITS PHARMACEUTICAL EVALUATION

Shama Parveen*, Jai Narayan Mishra, Dhaneshwar Kumar Vishwakarma and Navneet Kumar Verma

ABSTRACT

In the project work Enalapril maleate, an anti hypertensive drugs has been formulated into fast dissolving tablets by direct compression method using the different super disintegrates such as croscarmellose and sodium starch glycolate and Excipients like lactose, sucrose magnesium stearate, sodium lauryl sulphate the prepared by the tablets were evaluated for the pre-compression parameter UV Spectroscopy, post compression parameter such as thickness, hardness, friability, drugs contents, weight variation, water absorbance ratio, invitro disintegrating time, invitro dissolution studies. No chemical interaction between drugs and Excipients was conforming by FTIR study. All the parameter shows good results. Fast dissolving tablets are prepared by direct compression method are results found to be that among of nine formulation as the F9 to be best as its shows in F9 87.10% (direct compression method) maximum drug release respectively. The prepared tablets stability tested at 400c having 75% relativity humidity for 1month and found to be stable. Prepared fast dissolving tablets of Enalapril maleate 5 mg was found to be under fasting fed condition.

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