World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

PROTECTION OF TESTIS THROUGH ANTIOXIDANT ACTION OF OF ARTEMISIA ANNUA (KAYSOM) IN ALLOXAN-INDUCED DIABETIC ALBINO RATS

Ali Hassan A. Ali*

ABSTRACT

Background: Diabetes mellitus is a common metabolic disease and widely distributed all over the world. Most diabetic patients were associated with reproductive impairments.Previous studies reported negative complications of diabetes on the male reproductive system with associated gonadal dysfunction. Medicinal plants are effective enhancer of oxidative stress associated with diabetes mellitus. The current study was aimed at assessing the importance of supplementation of Artemisia annua (Kaysom) extract in reducing the metabolic abnormalities accompanied with alloxan-induced diabetes in male albino rats. Material and Methods: This study was conducted on thirty male albino rats with an average 100-110 g body weight. The rats were divided into three equal groups including control, diabetic and diabetic treated with Kaysom extract. One dose of alloxan (120 mg/kg body weight) was used to induce diabetes in rats. Diabetic rats were administered ?28.5 mg/kg body wt. twice/day? Kaysom extract orally for 30 days. Results: It has been detected that the morphological testicular changes noted in diabetic groups had been considerably improved after treatment with Kaysom extract compared with the control group. Conclusion: These results explained that Kaysom extract improves diabetes induced oxidative damage in testis as well as provides protection to testis.

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