World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

STUDY OF THE KINETICS AND MECHANISM OF OXIDATION REACTION OF AMBROXOL HYDROCHLORIDE DRUG WITH CHLORAMINE-T IN NAOH MEDIUM

Fathyah Omar Abdulsalam and Dr. Asha Iyengar*

ABSTRACT

Kinetics of oxidation of Ambroxol Hydrochloride (ABL) drug by Chloramine-T (CAT) in NaOH at 308 K has been investigated by iodometry. The reaction showed first-order dependence of rate on [CAT] and [ABL]o and inverse fractional-order dependence on [OH-] and [PTS]. The stoichiometry of the reaction was found to be 1:1 with respect to the substrate and oxidant respectively. The oxidation products were identified by spectral and FTIR analysis. Variation of ionic strength had no effect on the rate. Addition of p-toluenesulfonamide (PTS) retarded the rate of reaction. Activation parameters have been computed. Probable mechanism and the derived rate law have been proposed to explain the observed kinetic results.

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