World Journal of
Pharmaceutical and Life Sciences

OSTEOPOROSIS IN LIVER CIRRHOSIS

*Hozaifa Iqbal, Ayesha Bibi and Madiha Dar

ABSTRACT

Objective; To determine the cases suffering form osteoporosis in cases of liver cirrhosis. Methods; This study was done at Medicine department of Sir Ganga Ram Hospital, Lahore during July to December 2017. The cases were selected of either gender and age via non-probability consecutive sampling in this cross sectional study. The diagnosis of liver cirrhosis was made on the basis of signs and symptoms like jaundice, loss of appetite, abdominal distension and on USG as hepatic parenchymal changes with or without splenomegaly lasting for at leasing one year (assessed by medical record). The cases with metabolic disorders, renal failure and on chemotherapy were excluded. Osteoporosis was labeled as yes when the T score was less than 2.5 on DEXA scan. Results; In the present study out of 100 cases of liver cirrhosis, 64% were males. The mean age of the cases was 51.67±9.14 years and mean duration of liver cirrhosis was 7.23±1.45 years. Osteoporosis was observed in 30 (30%) of the cases. there was no significant difference of osteoporosis in terms of gender with p= 095. Osteoporosis was significantly high in cases with age more than 50 years affecting 22 (37.93%) of the cases with p= 0.04. this difference was also significant in cases that had liver cirrhosis for more than 3 years and was seen in 26 (36.11%) of the cases with p= 0.03 Conclusion; Osteoporosis is see in 1/3rd cases of cirrhosis and is significantly high in age more than 50 years and cirrhosis duration more than 3 years.

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