World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

FORMULATION AND PHYSICAL STABILITY TEST OF MICROEMULSION GEL OF KETOCONAZOLE

Hilda Nur Aziza and Mahdi Jufri*

ABSTRACT

Objective: The purpose of this study was to formulate and evaluate the physical stability of ketoconazole microemulsion gel. Method: Pseudoternary phase diagrams were constructed using tween 80 as surfactant and propylene glycol as co-surfactant. The optimized microemulsion formula containing 5% isopropyl myristate as oil phase, 25% Tween 80 as surfactant, and 25% propylene glycol as co-surfactant. Result: The formulation showed clear and transparent yellowish microemulsion, while the microemulsion gel showed cloudy yellowish color. Globule size in each microemulsion and microemulsion at were 13.38 nm and 184.7 nm; respectively. The flow diagram of the microemulsion gel properties showed the plastic flow properties. The centrifugation and cycling test result showed an unchanged organoleptic, no phase separation occured between microemulsion and gel, no syneresis occured. The result of cycling test and centrifugation test was physically stable. Conclusion: Ketoconazole microemulsion gel show a good stability at temperature 30°C ± 2°C and 40°C ± 2°C.

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