World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

HYPERSPLENISM AND LIVER CIRRHOSIS

*Dr. Aftab Alem Jehangir, Umar Raza and Arifa Khan

ABSTRACT

Objective: To determine the frequency of cases with hypersplenism presenting with liver cirrhosis. Methodology: This was a cross sectional study conducted at Sheikh Zayed Hospital, Rahim Yar Khan. In this study the diagnosed cases of liver cirrhosis of at least one year or more were included. The cases of age more than 20 years irrespective of gender were selected. Liver cirrhosis was labelled where the liver was shrunken and portal vein was more than 1 cm with or without signs and symptoms of cirrhosis. Detailed clinical and laboratory investigation s were conducted to label the Child Pugh Class. The cases with bleeding disorders and haematological malignancies were excluded. The diagnosis of hypersplenism was made on bone marrow analysis showing normal or hyper cellular marrow. Results: In this study there were total 100 cases out of which 57 (57%) were males and 43 (43%) females. The mean age was 53.45±8.11 years. Majority of the cases were seen in Child class B affecting 52 (52% of the cases. Hypersplenism was observed in 43 (43%) of the cases. Hypersplenism was seen more in cases with liver cirrhosis more than 2 years where it was observed in 37 (58.73%) out of 63 cases with p= 0.02. It was also seen more in cases with child pugh class C where it was noted in 34 (70.83%) out of 48 cases with p value of 0.001. Conclusion: Hypersplenism is seen in almost half of the cases with cirrhosis and is more in cases with Child class C and duration of cirrhosis > 2 years.

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