World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, 

Abstract

POST MARKET EVALUATION OF DIFFERENT BRANDS OF PARACETAMOL (500 MG) TABLET AVAILABLE IN RURAL AREA OF NAGPUR

Shikha D. Popali*, Rashmi R. Mishra, Rajesh A. Sahu, Amit N. Maliye, Madhav P. Sonekar

ABSTRACT

Paracetamol tablets are popular over the counter (OTC) products among the patients as a good analgesics and the objective of this study was to compare the quality of the Paracetamol tablet formulations those are locally available in rural market of Nagpur. The four popular brands (A, B, C, D) of Paracetamol conventional tablet of 500 mg strength were chosen. The quality of tablet formulations of different brands for various official parameters like friability, weight variation, disintegration time, dissolution and drug assay tests were performed as per the pharmacopeia. The result of all these parameters of different brands was in the pharmacopoeial limits so it could be concluded that marketed pharmaceutical tablets of Paracetamol of these brands are safe, effective and efficacious as well as satisfy quality control limits of pharmacopeia. The objective of the study was to determine the biopharmaceutical and chemical equivalence of four brands of Paracetamol tablets marketed in rural area of Nagpur region. using in vitro tests. The physicochemical equivalence were assessed through the evaluation of both official and non-official standards such as uniformity of weight, friability, hardness, disintegration, assay and dissolution rate. All the brands complied with the official specifications for uniformity of weight, disintegration and dissolution tests.

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