World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

A VALIDATED STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD DEVELOPMENT FOR THE SIMULTANEOUS ESTIMATION OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN BULK AND TABLET DOSAGE FORMS

Aluri Akhileswar* and D. Dhachinamoorthi

ABSTRACT

A validated, reproducible, accurate, selective, quick and eco-friendly stability- indicating isocratic reverse phase liquid chromatography method for the quantitative estimation of Valsartan and Hydrochlorothiazide in bulk and tablet dosage forms was developed. Determination of selected drugs in this combination was achieved with a C18 column ?Kromasil 100-5C18 column, P134 250×4.6mm?, isocratic mode. For the best resolution mobile phase of composition Acetonitrile and phosphate buffer (48:52 v/v, pH 4) was used. The flow rate was 1ml/min and the eluents were quantified at 235 nm, using VWD detector. The retention times were 2.6 and 3.9 for Valsartan and Hydrochlorothiazide respectively. Established analytical parameters were validated as per ICH Q2b guidelines. The established method was found to be more stable even after the samples were exposed to different stress conditions as there is no ghost peaks were identified.

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