World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), 

Abstract

BIOACTIVITY AND FREE RADICAL SCAVENGING ABILITY OF AN ISOLATED TRITERPENOID SAPONIN FROM THE ROOT BARK OF MASSULARIA ACUMINATA SPP

Uduak S. Ukekpe* Harami M. Adamu, and Eno O. Ekanem

ABSTRACT

triterpenoid saponin was isolated from the methanol extract of the root bark of Massularia acuminata spp. The compound was identified as 3-O – ?- D- glucopyranosyl – (1-4)- ?- D- glucopyranosyl – (1-4)- ?- Dglucopyranosyl- olean -12-en-28-oic acid on the basis of chemical and spectral evidence of IR and NMR (1H, 13C, DEPT, 1H-1H COSY, HSQC and HMBC) data. The compound showed good inhibitory activity against the microorganisms, Salmonella spp, Staphylococcus aureus, Escherichia coli, Aspergillus niger and Candida albicans indicating that it is a bioactive compound. It was also found to possess antioxidant property by virtue of its high DPPH free radical scavenging ability of 73.09% at 100?g/ml, property that can make it relevant in stress management and cosmetic industry.

[Full Text Article]

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